Article
Comprehensive Next-Generation Sequencing Reveals Novel Predictive Biomarkers of Recurrence and Thoracic Toxicity Risks After Chemoradiation Therapy in Limited Stage Small Cell Lung Cancer.
International journal of radiation oncology, biology, physics - 1 Apr 2022
Li Li, Tang Shanshan, Yin Jiani C, Dong Lihua, Yang Zhe, Liu Yueping, Ma Jie, Chang Pengyu, Pang Jiaohui, Bao Hua, Mu Dianbin, Zheng Xiaoli, Aishajiang Reyida, He Kewen, Zhang Shaotong, Ni Meng, Wu Xue, Wang Xiaonan, Shao Yang, Wang Jun, Ge Hong, Yu Jinming, Yuan Shuanghu
Abstract excerpt
PURPOSE: Although definitive chemoradiation therapy (dCRT) remains the most effective treatment modality in limited stage small cell lung cancer (SCLC), some patients progress quickly or develop serious radiation-induced thoracic toxicity (RITT). Molecular correlates of response to dCRT remain to be explored. METHODS AND MATERIALS: Genomic profiling was performed retrospectively on 231 patients with limited-stage...
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