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Article

Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

PloS one - 25 Aug 2010

Hildebrandt Michelle A T, Komaki Ritsuko, Liao Zhongxing, Gu Jian, Chang Joe Y, Ye Yuanqing, Lu Charles, Stewart David J, Minna John D, Roth Jack A, Lippman Scott M, Cox James D, Hong Waun Ki, Spitz Margaret R, Wu Xifeng

Abstract excerpt

Treatment of non-small cell lung cancer (NSCLC) with radiotherapy or chemoradiotherapy is often accompanied by the development of esophagitis and pneumonitis. Identifying patients who might be at increased risk for normal tissue toxicity would help in determination of the optimal radiation dose to avoid these events. We profiled 59 single nucleotide polymorphisms (SNPs) from 37 inflammation-related genes in 173...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20811626
DOI: 10.1371/journal.pone.0012402
PMCID: PMC2928273

Genes

MIF
NOS3
PTGS2
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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