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Article

Incorporating single-nucleotide polymorphisms into the Lyman model to improve prediction of radiation pneumonitis.

International journal of radiation oncology, biology, physics - 1 Jan 2013

Tucker Susan L, Li Minghuan, Xu Ting, Gomez Daniel, Yuan Xianglin, Yu Jinming, Liu Zhensheng, Yin Ming, Guan Xiaoxiang, Wang Li-E, Wei Qingyi, Mohan Radhe, Vinogradskiy Yevgeniy, Martel Mary, Liao Zhongxing

Abstract excerpt

PURPOSE: To determine whether single-nucleotide polymorphisms (SNPs) in genes associated with DNA repair, cell cycle, transforming growth factor-β, tumor necrosis factor and receptor, folic acid metabolism, and angiogenesis can significantly improve the fit of the Lyman-Kutcher-Burman (LKB) normal-tissue complication probability (NTCP) model of radiation pneumonitis (RP) risk among patients with non-small cell...

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Identifiers

PMID: 22541966
DOI: 10.1016/j.ijrobp.2012.02.021
PMCID: PMC3521878

Genes

APEX1
XRCC1
XRCC3
MDM2
MTHFR
MTRR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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