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Article

Polymorphisms of homologous recombination genes and clinical outcomes of non-small cell lung cancer patients treated with definitive radiotherapy.

PloS one - 1 Jan 2011

Yin Ming, Liao Zhongxing, Huang Yu-Jing, Liu Zhensheng, Yuan Xianglin, Gomez Daniel, Wang Li-E, Wei Qingyi

Abstract excerpt

The repair of DNA double-strand breaks (DSBs) is the major mechanism to maintain genomic stability in response to irradiation. We hypothesized that genetic polymorphisms in DSB repair genes may affect clinical outcomes among non-small cell lung cancer (NSCLC) patients treated with definitive radio(chemo)therapy. We genotyped six potentially functional single nucleotide polymorphisms (SNPs) (i.e., RAD51...

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Topics

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Share to Carcinoma, Non-Small-Cell Lung
Share to DNA-Binding Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Share to Lung Neoplasms

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Share to Recombination, Genetic

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Source

Open in PubMed Open full text

Identifiers

PMID: 21647442
DOI: 10.1371/journal.pone.0020055
PMCID: PMC3102071

Genes

RAD51
XRCC2
NBN
XRCC3

Variants

rs1801320
rs1801320
rs1801320

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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