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Article

Inflammation-related genetic variants predict toxicity following definitive radiotherapy for lung cancer.

Clinical pharmacology and therapeutics - 1 Nov 2014

Pu X, Wang L, Chang J Y, Hildebrandt M A T, Ye Y, Lu C, Skinner H D, Niu N, Jenkins G D, Komaki R, Minna J D, Roth J A, Weinshilboum R M, Wu X

Abstract excerpt

Definitive radiotherapy improves locoregional control and survival in inoperable non-small cell lung cancer patients. However, radiation-induced toxicities (pneumonitis/esophagitis) are common dose-limiting inflammatory conditions. We therefore conducted a pathway-based analysis to identify inflammation-related single-nucleotide polymorphisms associated with radiation-induced pneumonitis or esophagitis. A total...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 25054431
DOI: 10.1038/clpt.2014.154
PMCID: PMC4206576

Genes

PRKCE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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