Article
Genetic variants of the LIN28B gene predict severe radiation pneumonitis in patients with non-small cell lung cancer treated with definitive radiation therapy.
European journal of cancer (Oxford, England : 1990) - 1 Jul 2014
Wen Juyi, Liu Hongliang, Wang Qiming, Liu Zhensheng, Li Yangkai, Xiong Huihua, Xu Ting, Li Peng, Wang Li-E, Gomez Daniel R, Mohan Radhe, Komaki Ritsuko, Liao Zhongxing, Wei Qingyi
Abstract excerpt
BACKGROUND: LIN28 is an RNA-binding protein that not only plays key roles in multiple cellular developmental processes and tumourigenesis, but also is involved in tissue inflammatory response. However, no published study has investigated associations between genetic variants in LIN28 and radiation-induced pneumonitis (RP) in patients with non-small cell lung cancer (NSCLC) treated with definitive radiation...
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