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Increased DNA methylation of Dnmt3b targets impairs leukemogenesis

5 Jan 2016

Abstract excerpt

The de novo DNA methyltransferases Dnmt3a and Dnmt3b are of crucial importance in hematopoietic stem cells. Dnmt3b has recently been shown to play a role in genic methylation. To investigate how Dnmt3b-mediated DNA methylation affects leukemogenesis, we analyzed leukemia development under conditions of high and physiological methylation levels in a tetracycline-inducible knock-in mouse model. High expression of...

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Identifiers

PMID: 26729896
DOI: 10.1182/blood-2015-07-655928

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