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Article

Transcriptomic changes including p53 dysregulation prime DNMT3A mutant cells for transformation.

EMBO reports - 1 Jun 2025

Lawrence Erin M, Cooray Amali, Kueh Andrew J, Pal Martin, Tai Lin, Garnham Alexandra L, Li-Wai-Suen Connie S N, Vanyai Hannah, Gouil Quentin, Lancaster James, Callegari Sylvie, Whelan Lauren, Lieschke Elizabeth, Thomas Annabella, Strasser Andreas, Liao Yang, Shi Wei, Wei Andrew H, Herold Marco J

Abstract excerpt

DNMT3A mutations are prevalent in haematologic malignancies. In our mouse model the murine homologue (R878H) of the human 'hotspot' R882H mutation is introduced into the mouse Dnmt3a locus. This results in globally reduced DNA methylation in all tissues. Mice with heterozygous R878H DNMT3A mutations develop γ-radiation induced thymic lymphoma more rapidly than control mice, suggesting a vulnerability to stress...

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Share to Cell Transformation, Neoplastic
Share to DNA (Cytosine-5-)-Methyltransferases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to DNA Methyltransferase 3A

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Source

Open in PubMed Open full text

Identifiers

PMID: 40307617
DOI: 10.1038/s44319-025-00450-4
PMCID: PMC12152194

Genes

DNMT3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

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