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Article

Dnmt3a loss predisposes murine hematopoietic stem cells to malignant transformation

22 Nov 2014

Abstract excerpt

DNA methyltransferase 3A (DNMT3A) is mutated in hematologic malignancies affecting myeloid, mixed, and lymphoid lineages, and these mutations are associated with poor prognosis. Past studies in mice revealed Dnmt3a-knockout (KO)hematopoietic stem cells (HSCs) had increased self-renewal, but no leukemia was observed. Here, all lethally irradiated mice transplanted with Dnmt3a-deleted HSCs died within 1 year....

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PMID: 25416277
DOI: 10.1182/blood-2014-08-594648

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