Article
DNMT3A Loss Drives Enhancer Hypomethylation in FLT3-ITD-Associated Leukemias.
Cancer cell - 13 Jun 2016
Yang Liubin, Rodriguez Benjamin, Mayle Allison, Park Hyun Jung, Lin Xueqiu, Luo Min, Jeong Mira, Curry Choladda V, Kim Sang-Bae, Ruau David, Zhang Xiaotian, Zhou Ting, Zhou Michael, Rebel Vivienne I, Challen Grant A, Gottgens Berthold, Lee Ju-Seog, Rau Rachel, Li Wei, Goodell Margaret A
Abstract excerpt
DNMT3A, the gene encoding the de novo DNA methyltransferase 3A, is among the most frequently mutated genes in hematologic malignancies. However, the mechanisms through which DNMT3A normally suppresses malignancy development are unknown. Here, we show that DNMT3A loss synergizes with the FLT3 internal tandem duplication in a dose-influenced fashion to generate rapid lethal lymphoid or myeloid leukemias similar to...
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