Article
DNMT3A in Leukemia.
Cold Spring Harbor perspectives in medicine - 1 Feb 2017
Brunetti Lorenzo, Gundry Michael C, Goodell Margaret A
Abstract excerpt
DNA methylation is an epigenetic process involved in development, aging, and cancer. Although the advent of new molecular techniques has enhanced our knowledge of how DNA methylation alters chromatin and subsequently affects gene expression, a direct link between epigenetic marks and tumorigenesis has not been established. DNMT3A is a de novo DNA methyltransferase that has recently gained relevance because of its...
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