Article
CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression.
Cell - 23 Feb 2017
Spencer David H, Russler-Germain David A, Ketkar Shamika, Helton Nichole M, Lamprecht Tamara L, Fulton Robert S, Fronick Catrina C, O'Laughlin Michelle, Heath Sharon E, Shinawi Marwan, Westervelt Peter, Payton Jacqueline E, Wartman Lukas D, Welch John S, Wilson Richard K, Walter Matthew J, Link Daniel C, DiPersio John F, Ley Timothy J
Abstract excerpt
DNMT3A mutations occur in ∼25% of acute myeloid leukemia (AML) patients. The most common mutation, DNMT3AR882H, has dominant negative activity that reduces DNA methylation activity by ∼80% in vitro. To understand the contribution of DNMT3A-dependent methylation to leukemogenesis, we performed whole-genome bisulfite sequencing of primary leukemic and non-leukemic cells in patients with or without DNMT3AR882...
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