Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling.

EBioMedicine - 1 Jan 2021

Lopusna Katarina, Nowialis Pawel, Opavska Jana, Abraham Ajay, Riva Alberto, Opavsky Rene

Abstract excerpt

BACKGROUND: DNA methylation regulates gene transcription in many physiological processes in mammals including development and haematopoiesis. It is catalysed by several DNA methyltransferases, including Dnmt3b that mediates both methylation-dependant and independent gene repression. Dnmt3b is critical for mouse embryogenesis and functions as a tumour suppressor in haematologic malignancies in mice. However, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Catalysis
Share to Cell Transformation, Neoplastic

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA (Cytosine-5-)-Methyltransferases

Share to DNA Methyltransferase 3B

Share to Enzyme Activation

Share to Lymphoma

Share to Receptor Protein-Tyrosine Kinases

Share to Tumor Suppressor Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 33418509
DOI: 10.1016/j.ebiom.2020.103191
PMCID: PMC7804970

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dnmt3b catalytic activity is critical for its tumour suppressor function in lymphomagenesis and is associated with c-Met oncogenic signalling.PMID 33418509Read ↗

Dnmt3b is a haploinsufficient tumor suppressor gene in Myc-induced lymphomagenesisSemantic proximity Read ↗

Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome.Semantic proximity Read ↗

DNA methyltransferases in hematological malignancies.Semantic proximity Read ↗

Dnmt3b Prefers Germ Line Genes and Centromeric Regions: Lessons from the ICF Syndrome and Cancer and Implications for DiseasesSemantic proximity Read ↗

Tissue-Biased Expansion of DNMT3A-Mutant Clones in a Mosaic Individual Is Associated with Conserved Epigenetic Erosion.Semantic proximity Read ↗

Loss of Dnmt3a induces CLL and PTCL with distinct methylomes and transcriptomes in miceSemantic proximity Read ↗

ICF syndrome mutations cause a broad spectrum of biochemical defects in DNMT3B-mediated de novo DNA methylation.Semantic proximity Read ↗

Base-Resolution Analysis of DNA Methylation Patterns Downstream of Dnmt3a in Mouse Naïve B Cells.Semantic proximity Read ↗

Alterations to DNMT3A in Hematologic Malignancies.Semantic proximity Read ↗

Increased DNA methylation of Dnmt3b targets impairs leukemogenesisSemantic proximity Read ↗

DNA methyltransferase 3B (DNMT3B) mutations in ICF syndrome lead to altered epigenetic modifications and aberrant expression of genes regulating development, neurogenesis and immune function.Semantic proximity Read ↗

Enforced differentiation of Dnmt3a-null bone marrow leads to failure with c-Kit mutations driving leukemic transformation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.