Article
DNA methyltransferases in hematological malignancies.
Journal of genetics and genomics = Yi chuan xue bao - 20 Jul 2020
Hoang Nguyet-Minh, Rui Lixin
Abstract excerpt
DNA methyltransferases (DNMTs) are an evolutionarily conserved family of DNA methylases, transferring a methyl group onto the fifth carbon of a cytosine residue. The mammalian DNMT family includes three major members that have functional methylation activities, termed DNMT1, DNMT3A, and DNMT3B. DNMT3A and DNMT3B are responsible for methylation establishment, whereas DNMT1 maintains methylation during DNA...
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