Article

Dnmt3a Is Essential for Hematopoietic Stem Cell Differentiation

2011-11-18

Abstract excerpt

Abstract Abstract 386 Aberrant genomic DNA methylation patterns are widely reported in human cancers but the prognostic value and pathological consequences of these marks remain uncertain. CpG methylation is catalyzed by a family of DNA methyltransferase enzymes comprised of three members – Dnmt1, Dnmt3a and Dnmt3b. Mutations in the de novo DNA methyltransferase enzyme DNMT3A have now been reported in over 20% of...

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Literature Corpus work: 9e61a4e0-a15c-58ec-8718-15ddee72cdd6
DOI: 10.1182/blood.v118.21.386.386

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