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Article

DNA methyltransferases in hematologic malignancies.

Seminars in hematology - 1 Jan 2013

Li Keqin Kathy, Luo Liu-Fei, Shen Yang, Xu Jie, Chen Zhu, Chen Sai-Juan

Abstract excerpt

DNA methyltransferases (DNMTs) are the key enzymes for genome methylation, which plays an important role in epigenetically regulated gene expression and repression. Mouse models with conditional knockout of the DNA methyltransferase 1 (DNMT1) and DNA methyltransferase 3A (DNMT3A) genes have revealed a role of DNA methylation in mediating the self-renewal and differentiation of normal hematopoietic stem cells...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23507483
DOI: 10.1053/j.seminhematol.2013.01.005

Genes

DNMT1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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