Article

Transcriptomic alterations including p53 pathway dysregulation prime DNMT3A mutant cells for transformation

2024-08-12

Abstract excerpt

DNMT3A mutations are prevalent in haematologic malignancies. Our mouse model introduced the murine homologue (R878H) of the human hotspot R882H mutation into the mouse Dnmt3a locus, resulting in globally reduced DNA methylation in all tissues. Mice with heterozygous R878H mutations developed gamma-radiation induced thymic lymphoma more rapidly than control mice, suggesting a vulnerability to stress stimuli in Dnmt...

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Literature Corpus work: 4b2d0747-e2eb-543f-8dd8-4c440d692d5a
DOI: 10.1101/2024.08.12.607467

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