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Article

Retinal Phenotype following Combined Deletion of the Chemokine Receptor CCR2 and the Chemokine CX3CL1 in Mice.

Ophthalmic research - 1 Jan 2016

Hagbi-Levi Shira, Grunin Michelle, Elbaz-Hayoun Sarah, Tal David, Obolensky Alexey, Hanhart Joel, Banin Eyal, Burstyn-Cohen Tal, Chowers Itay

Abstract excerpt

PURPOSE: Conflicting data were reported with respect to the retinal phenotype of mice with dual perturbation of the CCL2 and CX3CR1 genes. We report the generation and retinal phenotype of mice with a reverse CCR2/CX3CL1 gene deficiency as a suggested model for age-related macular degeneration (AMD). METHODS: Crossing of single-deficient mice generated CCR2/CX3CL1 DKO mice. DKO mice were compared with age-matched...

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Source

Identifiers

PMID: 26670885
DOI: 10.1159/000441794

Genes

CCR2
ERG
RPE
CCL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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