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Article

Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling.

PloS one - 1 Jan 2012

Luhmann Ulrich F O, Lange Clemens A, Robbie Scott, Munro Peter M G, Cowing Jill A, Armer Hannah E J, Luong Vy, Carvalho Livia S, MacLaren Robert E, Fitzke Frederick W, Bainbridge James W B, Ali Robin R

Abstract excerpt

Microglia and macrophages are recruited to sites of retinal degeneration where local cytokines and chemokines determine protective or neurotoxic microglia responses. Defining the role of Ccl2-Ccr2 and Cx3cl1-Cx3cr1 signalling for retinal pathology is of particular interest because of its potential role in age-related macular degeneration (AMD). Ccl2, Ccr2, and Cx3cr1 signalling defects impair macrophage...

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Share to Chemokine CCL2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 22545116
DOI: 10.1371/journal.pone.0035551
PMCID: PMC3335860

Genes

RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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