Article
Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration.
Journal of neuroinflammation - 12 Oct 2015
Kohno Hideo, Koso Hideto, Okano Kiichiro, Sundermeier Thomas R, Saito Saburo, Watanabe Sumiko, Tsuneoka Hiroshi, Sakai Tsutomu
Abstract excerpt
BACKGROUND: Though accumulating evidence suggests that microglia, resident macrophages in the retina, and bone marrow-derived macrophages can cause retinal inflammation which accelerates photoreceptor cell death, the details of how these cells are activated during retinal degeneration (RD) remain uncertain. Therefore, it is important to clarify which cells play a dominant role in fueling retinal inflammation....
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