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Article

Ccl2/Cx3cr1 knockout mice have inner retinal dysfunction but are not an accelerated model of AMD.

Investigative ophthalmology & visual science - 27 Nov 2012

Vessey Kirstan A, Greferath Ursula, Jobling Andrew I, Phipps Joanna A, Ho Tracy, Waugh Michelle, Fletcher Erica L

Abstract excerpt

PURPOSE: The chemokine, Ccl2, and the fractalkine receptor, Cx3cr1, have both been implicated in the pathogenesis of age related macular degeneration (AMD), with mice lacking both genes exhibiting features of AMD by 3 months of age. However, recent reports indicate that this ascribed phenotype is due to the presence of a retinal degeneration mutation (crb1(rd8/rd8), rd8) on the background strain. Our aim was to...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23074204
DOI: 10.1167/iovs.12-10650

Genes

ERG
RPE

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Ccl2/Cx3cr1 knockout mice have inner retinal dysfunction but are not an accelerated model of AMD.PMID 23074204Read ↗

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