Article

Infiltrating monocytes augment alternative complement activation and exacerbate inherited retinal degeneration in a mouse model

2026-05-28

Abstract excerpt

<title>Abstract</title> <p>In retinal degenerative disease, microglia and macrophages accumulate at sites of pathology and strongly influence disease progression, yet their distinct contributions remain unclear. To define the fate and function of infiltrating monocyte-derived macrophages (MDM) in retinal degeneration, we generated a CCR2-CreER mouse line on the rd10 background to enable precise monocyte-specific...

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Literature Corpus work: cac35a43-177f-53b3-9b53-ee3ec8583f07
DOI: 10.21203/rs.3.rs-8734757/v1

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