Article

Deletion of Socs3 in LysM+ Cells and Cx3cr1 Resulted in Age-dependent Development of Retinal Microgliopathy

2020-08-10

Abstract excerpt

<title>Abstract</title> <p>BackgroundWe generated a mouse model of primary microglial dysfunction by deleting two negative immune regulatory genes, <italic>Cx3cr1</italic> and <italic>Socs3</italic> (in LysM<sup>+</sup> cells). This study aimed to understand how primary microglial dysfunction impacts retinal neurons during aging.MethodsThe <italic>LysMCre-Socs3</italic><sup><italic>fl/fl</italic></sup><italic>Cx3...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 901a0d27-8e13-5005-8178-347e58209013
DOI: 10.21203/rs.3.rs-47513/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Deletion of Socs3 in LysM+ Cells and Cx3cr1 Resulted in Age-dependent Development of Retinal MicrogliopathyDOI 10.21203/rs.3.rs-47513/v1Read

Deletion of Socs3 in LysM+ cells and Cx3cr1 resulted in age-dependent development of retinal microgliopathySemantic proximity Read

Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal modelSemantic proximity Read

Microglial Cell Dysfunction in CRB1-Associated Retinopathies.Semantic proximity Read

RasV12 Expression in Microglia Promotes Retinal Inflammatory Circuits and Impairment of PhotoreceptorSemantic proximity Read

Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa.Semantic proximity Read

Microglia at Sites of Atrophy Restrict the Progression of Retinal Degeneration via Galectin-3 and Trem2 InteractionsSemantic proximity Read

Soluble CX3CL1 gene therapy improves cone survival and function in mouse models of retinitis pigmentosaSemantic proximity Read

Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue lightSemantic proximity Read

More than meets the eye: The role of microglia in healthy and diseased retinaSemantic proximity Read

Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration.Semantic proximity Read

E3 ubiquitin ligase Herc3 deficiency leads to accumulation of subretinal microglia and retinal neurodegenerationSemantic proximity Read

Deciphering perivascular macrophages and microglia in the retinal ganglion cell layersSemantic proximity Read