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Article

Deletion of Socs3 in LysM+ cells and Cx3cr1 resulted in age-dependent development of retinal microgliopathy

18 Feb 2021

Abstract excerpt

Abstract Background We generated a mouse model of primary microglial dysfunction by deleting two negative immune regulatory genes, Cx3cr1 and Socs3 (in LysM + cells). This study aimed to understand how primary microglial dysfunction impacts retinal neurons during aging. Methods The LysMCre-Socs3 fl/fl Cx3cr1 gfp/gfp double knockout (DKO), LysMCre-Socs3 fl/fl , Cx3cr1 gfp/gfp and Socs3 fl/fl mice were maintained...

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Share to Neuroinflammation and Neurodegeneration Mechanisms
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PMID: 33602265
DOI: 10.1186/s13024-021-00432-9

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