Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue light

10 Nov 2016

Abstract excerpt

Abstract Age-related macular degeneration (AMD), the leading cause of visual loss after the age of 60 years, is a degenerative retinal disease involving a variety of environmental and hereditary factors. Although it has been implicated that immune system is involved in the disease progression, the exact role that microglia has is still unclear. Here we demonstrated that knockout of Ccr2 gene could alleviate...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Neuroinflammation and Neurodegeneration Mechanisms
Share to Ocular Diseases and Behçet’s Syndrome
Share to Retinal Diseases and Treatments

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27831552
DOI: 10.1038/cddis.2016.363

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue lightPMID 27831552Read ↗

Suppression of microglial activation is neuroprotective in a mouse model of human retinitis pigmentosa.Semantic proximity Read ↗

Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration.Semantic proximity Read ↗

Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling.Semantic proximity Read ↗

Retinal Phenotype following Combined Deletion of the Chemokine Receptor CCR2 and the Chemokine CX3CL1 in Mice.Semantic proximity Read ↗

Microglial Cell Dysfunction in CRB1-Associated Retinopathies.Semantic proximity Read ↗

Role of microglial cells in photoreceptor degenerationSemantic proximity Read ↗

CCR1 Mediates Müller Cell Activation and Photoreceptor Cell Death in Macular and Retinal DegenerationSemantic proximity Read ↗

CCR1 Signaling as a Common Injury Pathway in Retinal DegenerationSemantic proximity Read ↗

Retinal pigment epithelium-derived PD-L1 reprograms microglial cells and protects against retinal degeneration in mouse models of experimental AMD and genetic retinitis pigmentosaSemantic proximity Read ↗

Necroptosis in microglia contributes to neuroinflammation and retinal degeneration through TLR4 activation.Semantic proximity Read ↗

IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative DiseasesSemantic proximity Read ↗

Investigating Chemokine-Induced NF-κB Activation in Retinal Cells and Its Contribution to Age-Related Macular Degeneration Pathogenesis: A Systematic ReviewSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.