Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Immunological protein expression profile in Ccl2/Cx3cr1 deficient mice with lesions similar to age-related macular degeneration.

Experimental eye research - 1 Apr 2008

Ross Robert J, Zhou Min, Shen Defen, Fariss Robert N, Ding Xiaoyan, Bojanowski Christine M, Tuo Jingsheng, Chan Chi-Chao

Abstract excerpt

Age-related macular degeneration (AMD) is the leading cause of blindness in the United States. Ccl2 knock-out (KO) mice sporadically develop the cardinal features of AMD in their senescent stage. Humans bearing a loss of function variant or single nucleotide polymorphism (SNP) in CX3CR1 are at increased risk of developing AMD. We recently developed Ccl2(-/-)/Cx3cr1(-/-) mice, which consistently develop retinal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Capillaries
Share to Chemokine CCL2

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Choroid

Share to Complement C3

Share to CX3C Chemokine Receptor 1

Share to Pigment Epithelium of Eye

Share to Receptors, Chemokine

Share to Uveitis

Source

Open in PubMed Open full text

Identifiers

PMID: 18308304
DOI: 10.1016/j.exer.2008.01.014
PMCID: PMC2375389

Genes

RPE
TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Immunological protein expression profile in Ccl2/Cx3cr1 deficient mice with lesions similar to age-related macular degeneration.PMID 18308304Read ↗

Ccl2, Cx3cr1 and Ccl2/Cx3cr1 chemokine deficiencies are not sufficient to cause age-related retinal degeneration.Semantic proximity Read ↗

Retinal Phenotype following Combined Deletion of the Chemokine Receptor CCR2 and the Chemokine CX3CL1 in Mice.Semantic proximity Read ↗

Differential modulation of retinal degeneration by Ccl2 and Cx3cr1 chemokine signalling.Semantic proximity Read ↗

CCL2/CCR2 and CX3CL1/CX3CR1 chemokine axes and their possible involvement in age-related macular degeneration.Semantic proximity Read ↗

Ccl2/Cx3cr1 knockout mice have inner retinal dysfunction but are not an accelerated model of AMD.Semantic proximity Read ↗

Knockout of Ccr2 alleviates photoreceptor cell death in rodent retina exposed to chronic blue lightSemantic proximity Read ↗

Age-related macular degeneration phenotypes are associated with increased tumor necrosis-alpha and subretinal immune cells in aged Cxcr5 knockout mice.Semantic proximity Read ↗

Differences in the distribution, phenotype and gene expression of subretinal microglia/macrophages in C57BL/6N (Crb1 rd8/rd8) versus C57BL6/J (Crb1 wt/wt) mice.Semantic proximity Read ↗

Infiltrating monocytes augment alternative complement activation and exacerbate inherited retinal degeneration in a mouse modelSemantic proximity Read ↗

Expression pattern of Ccr2 and Cx3cr1 in inherited retinal degeneration.Semantic proximity Read ↗

CX3CR1-dependent subretinal microglia cell accumulation is associated with cardinal features of age-related macular degeneration.Semantic proximity Read ↗

Immune Activation in Retinal Aging: A Gene Expression StudySemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.