Article

CCR1 Signaling as a Common Injury Pathway in Retinal Degeneration

2026-02-22

Abstract excerpt

<title>Abstract</title> <p> Inflammation is a key driver of atrophic Age-Related Macular Degeneration (aAMD), and also plays a role in Inherited Retinal Degenerations (IRDs), two major causes of irreversible visual loss. We previously demonstrated that the chemokine receptor CCR1 is upregulated in monocytes from AMD patients, and that it mediates the recruitment of neurotoxic macrophages and activates Müller gli...

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Literature Corpus work: ae163031-d561-54e7-81f5-d21188de261b
DOI: 10.21203/rs.3.rs-8775900/v1

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