Article
RNA-seq reveals post-transcriptional regulation of Drosophila insulin-like peptide dilp8 and the neuropeptide-like precursor Nplp2 by the exoribonuclease Pacman/XRN1.
Nucleic acids research - 8 Jan 2016
Jones Christopher I, Pashler Amy L, Towler Benjamin P, Robinson Sophie R, Newbury Sarah F
Abstract excerpt
Ribonucleases are critically important in many cellular and developmental processes and defects in their expression are associated with human disease. Pacman/XRN1 is a highly conserved cytoplasmic exoribonuclease which degrades RNAs in a 5'-3' direction. In Drosophila, null mutations in pacman result in small imaginal discs, a delay in onset of pupariation and lethality during the early pupal stage. In this...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.