Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

XRN 5'→3' exoribonucleases: structure, mechanisms and functions.

Biochimica et biophysica acta - 1 Jan 2000

Nagarajan Vinay K, Jones Christopher I, Newbury Sarah F, Green Pamela J

Abstract excerpt

The XRN family of 5'→3' exoribonucleases is critical for ensuring the fidelity of cellular RNA turnover in eukaryotes. Highly conserved across species, the family is typically represented by one cytoplasmic enzyme (XRN1/PACMAN or XRN4) and one or more nuclear enzymes (XRN2/RAT1 and XRN3). Cytoplasmic and/or nuclear XRNs have proven to be essential in all organisms tested, and deficiencies can have severe...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Nucleus
Share to Cytoplasm
Share to Drosophila

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drosophila Proteins

Share to Eukaryota

Share to Exoribonucleases

Share to Microtubule-Associated Proteins

Share to RNA Stability

Source

Open in PubMed Open full text

Identifiers

PMID: 23517755
DOI: 10.1016/j.bbagrm.2013.03.005
PMCID: PMC3742305

Genes

XRN1
XRN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

XRN 5'→3' exoribonucleases: structure, mechanisms and functions.PMID 23517755Read ↗

The roles of the exoribonucleases DIS3L2 and XRN1 in human diseaseSemantic proximity Read ↗

Proper 5'-3' cotranslational mRNA decay in yeast requires import of Xrn1 to the nucleus.Semantic proximity Read ↗

Identification and developmental expression of a 5'-3' exoribonuclease from Drosophila melanogaster.Semantic proximity Read ↗

SKI complex: A multifaceted cytoplasmic RNA exosome cofactor in mRNA metabolism with links to disease, developmental processes, and antiviral responsesSemantic proximity Read ↗

Structure and function of the 5'-->3' exoribonuclease Rat1 and its activating partner Rai1.Semantic proximity Read ↗

RNA degradation by the plant RNA exosome involves both phosphorolytic and hydrolytic activities.Semantic proximity Read ↗

Coupled 5' nucleotide recognition and processivity in Xrn1-mediated mRNA decay.Semantic proximity Read ↗

High-throughput siRNA screening reveals functional interactions and redundancies of human processive exoribonucleasesSemantic proximity Read ↗

Mechanism and structural diversity of exoribonuclease-resistant RNA structures in flaviviral RNAsSemantic proximity Read ↗

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts.Semantic proximity Read ↗

<i>De novo</i> truncation variants in the low-complexity C-terminal region of <i>XRN1</i> are associated with a dominant form of lethal infantile mitochondrial cardiomyopathySemantic proximity Read ↗

Shared properties and singularities of exoribonuclease-resistant RNAs in virusesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.