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Article

The roles of the exoribonucleases DIS3L2 and XRN1 in human disease

15 Oct 2016

Abstract excerpt

RNA degradation is a vital post-transcriptional process which ensures that transcripts are maintained at the correct level within the cell. DIS3L2 and XRN1 are conserved exoribonucleases that are critical for the degradation of cytoplasmic RNAs. Although the molecular mechanisms of RNA degradation by DIS3L2 and XRN1 have been well studied, less is known about their specific roles in the development of...

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PMID: 27911720
DOI: 10.1042/bst20160107

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