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Article

Identification and developmental expression of a 5'-3' exoribonuclease from Drosophila melanogaster.

Mechanisms of development - 1 Dec 1998

Till D D, Linz B, Seago J E, Elgar S J, Marujo P E, Elias M L, Arraiano C M, McClellan J A, McCarthy J E, Newbury S F

Abstract excerpt

In multicellular organisms, very little is known about the role of mRNA stability in development, and few proteins involved in degradation pathways have been characterized. We have identified the Drosophila homologue of XRN1, which is the major cytoplasmic 5'-3' exoribonuclease in Saccharomyces cerevisiae. The protein sequence of this homologue (pacman) has 59% identity to S. cerevisiae XRN1 and 67% identity to...

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Source

Identifiers

PMID: 10349620
DOI: 10.1016/s0925-4773(98)00173-7

Genes

XRN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Identification and developmental expression of a 5'-3' exoribonuclease from Drosophila melanogaster.PMID 10349620Read ↗

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XRN 5'→3' exoribonucleases: structure, mechanisms and functions.Semantic proximity Read ↗

The 5'-3' exoribonuclease pacman is required for epithelial sheet sealing in Drosophila and genetically interacts with the phosphatase puckered.Semantic proximity Read ↗

The roles of the exoribonucleases DIS3L2 and XRN1 in human diseaseSemantic proximity Read ↗

Mutational analysis of exoribonuclease I from Saccharomyces cerevisiae.Semantic proximity Read ↗

RNA-seq reveals post-transcriptional regulation of Drosophila insulin-like peptide dilp8 and the neuropeptide-like precursor Nplp2 by the exoribonuclease Pacman/XRN1.Semantic proximity Read ↗

Characterisation of the <i>in-vivo</i> miRNA landscape in <i>Drosophila</i> ribonuclease mutants reveals Pacman mediated regulation of the highly conserved <i>let-7</i> cluster during apoptotic processesSemantic proximity Read ↗

AtXRN4 degrades mRNA in Arabidopsis and its substrates include selected miRNA targets.Semantic proximity Read ↗

The Conserved RNA Exonuclease Rexo5 Is Required for 3' End Maturation of 28S rRNA, 5S rRNA, and snoRNAs.Semantic proximity Read ↗

Proper 5'-3' cotranslational mRNA decay in yeast requires import of Xrn1 to the nucleus.Semantic proximity Read ↗

Genome-wide analyses of XRN1-sensitive targets in osteosarcoma cells identifies disease-relevant transcripts containing G-rich motifsSemantic proximity Read ↗

Rat1p and Xrn1p are functionally interchangeable exoribonucleases that are restricted to and required in the nucleus and cytoplasm, respectively.Semantic proximity Read ↗

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