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Article

The RNA exosome maintains cellular RNA homeostasis by controlling transcript abundance in the brain.

Cell reports - 27 Jan 2026

Higginson Lauryn A, Wang Xingjun, He Kevin, Torstrick Maggie, Kim Minhoo, Wijeratne H R Sagara, Runnebohm Avery M, Benayoun Bérénice A, MacLean Adam, Chanfreau Guillaume F, Morton Derrick J

Abstract excerpt

Intracellular ribonucleases (RNases) are essential for maintaining accurate RNA levels. Inherited mutations in genes encoding ubiquitous RNases are associated with human diseases, primarily affecting the nervous system. Recessive mutations in genes encoding the evolutionarily conserved RNA exosome, an RNase complex, cause syndromic neurodevelopmental disorders, such as pontocerebellar hypoplasia type 1b (PCH1b),...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 41417727
DOI: 10.1016/j.celrep.2025.116729
PMCID: PMC12952294

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