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Article

Drosophila CG3303 is an essential endoribonuclease linked to TDP-43-mediated neurodegeneration.

Scientific reports - 31 Jan 2017

Laneve Pietro, Piacentini Lucia, Casale Assunta Maria, Capauto Davide, Gioia Ubaldo, Cappucci Ugo, Di Carlo Valerio, Bozzoni Irene, Di Micco Patrizio, Morea Veronica, Di Franco Carmela Antonia, Caffarelli Elisa

Abstract excerpt

Endoribonucleases participate in almost every step of eukaryotic RNA metabolism, acting either as degradative or biosynthetic enzymes. We previously identified the founding member of the Eukaryotic EndoU ribonuclease family, whose components display unique biochemical features and are flexibly involved in important biological processes, such as ribosome biogenesis, tumorigenesis and viral replication. Here we...

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PMID: 28139767
DOI: 10.1038/srep41559
PMCID: PMC5282483

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