Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The 5'-3' exoribonuclease Pacman (Xrn1) regulates expression of the heat shock protein Hsp67Bc and the microRNA miR-277-3p in Drosophila wing imaginal discs.

RNA biology - 1 Aug 2013

Jones Christopher I, Grima Dominic P, Waldron Joseph A, Jones Sue, Parker Hannah N, Newbury Sarah F

Abstract excerpt

Pacman/Xrn1 is a highly conserved exoribonuclease known to play a critical role in gene regulatory events such as control of mRNA stability, RNA interference and regulation via miRNAs. Although Pacman has been well studied in Drosophila tissue culture cells, the biologically relevant cellular pathways controlled by Pacman in natural tissues are unknown. This study shows that a hypomorphic mutation in pacman (pcm...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Drosophila
Share to Drosophila Proteins

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Exoribonucleases

Share to Gene Expression Regulation, Developmental

Share to Heat-Shock Proteins

Share to Imaginal Discs

Share to MicroRNAs

Share to Wings, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 23792537
DOI: 10.4161/rna.25354
PMCID: PMC3817156

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The 5'-3' exoribonuclease Pacman (Xrn1) regulates expression of the heat shock protein Hsp67Bc and the microRNA miR-277-3p in Drosophila wing imaginal discs.PMID 23792537Read ↗

The 5'-3' exoribonuclease pacman is required for epithelial sheet sealing in Drosophila and genetically interacts with the phosphatase puckered.Semantic proximity Read ↗

Identification and developmental expression of a 5'-3' exoribonuclease from Drosophila melanogaster.Semantic proximity Read ↗

RNA-seq reveals post-transcriptional regulation of Drosophila insulin-like peptide dilp8 and the neuropeptide-like precursor Nplp2 by the exoribonuclease Pacman/XRN1.Semantic proximity Read ↗

Characterisation of the <i>in-vivo</i> miRNA landscape in <i>Drosophila</i> ribonuclease mutants reveals Pacman mediated regulation of the highly conserved <i>let-7</i> cluster during apoptotic processesSemantic proximity Read ↗

XRN 5'→3' exoribonucleases: structure, mechanisms and functions.Semantic proximity Read ↗

Genome-wide analyses of XRN1-sensitive targets in osteosarcoma cells identifies disease-relevant transcripts containing G-rich motifsSemantic proximity Read ↗

A yeast exosome cofactor, Mpp6, functions in RNA surveillance and in the degradation of noncoding RNA transcripts.Semantic proximity Read ↗

The Conserved RNA Exonuclease Rexo5 Is Required for 3' End Maturation of 28S rRNA, 5S rRNA, and snoRNAs.Semantic proximity Read ↗

Loss of Arabidopsis 5'-3' Exoribonuclease AtXRN4 Function Enhances Heat Stress Tolerance of Plants Subjected to Severe Heat Stress.Semantic proximity Read ↗

The roles of the exoribonucleases DIS3L2 and XRN1 in human diseaseSemantic proximity Read ↗

AtXRN4 degrades mRNA in Arabidopsis and its substrates include selected miRNA targets.Semantic proximity Read ↗

Loss of the Drosophila melanogaster DEAD box protein Ddx1 leads to reduced size and aberrant gametogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.