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Article

The ribonuclease Dis3 is an essential regulator of the developmental transcriptome.

BMC genomics - 1 Aug 2012

Hou Dezhi, Ruiz Miriam, Andrulis Erik D

Abstract excerpt

BACKGROUND: Dis3 is ribonuclease that acts directly in the processing, turnover, and surveillance of a large number of distinct RNA species. Evolutionarily conserved from eubacteria to eukaryotes and a crucial component of the RNA processing exosome, Dis3 has been shown to be essential in yeast and fly S2 cells. However, it is not known whether Dis3 has essential functions in a metazoan. This study inquires...

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Identifiers

PMID: 22853036
DOI: 10.1186/1471-2164-13-359
PMCID: PMC3434026

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