Article

The RNA exosome maintains cellular RNA homeostasis by controlling transcript abundance in the brain

2024-10-30

Abstract excerpt

Intracellular ribonucleases (RNases) are essential in all aspects of RNA metabolism, including maintaining accurate RNA levels. Inherited mutations in genes encoding ubiquitous RNases are associated with human diseases, primarily affecting the nervous system. Recessive mutations in genes encoding an evolutionarily conserved RNase complex, the RNA exosome, lead to syndromic neurodevelopmental disorders characterize...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 106817aa-7402-5b5a-a413-f13c33249160
DOI: 10.1101/2024.10.30.620488

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The RNA exosome maintains cellular RNA homeostasis by controlling transcript abundance in the brainDOI 10.1101/2024.10.30.620488Read

The RNA exosome maintains cellular RNA homeostasis by controlling transcript abundance in the brain.Semantic proximity Read

A Drosophila model of Pontocerebellar Hypoplasia reveals a critical role for the RNA exosome in neurons.Semantic proximity Read

A <i>Drosophila</i> Model of Pontocerebellar Hypoplasia Reveals a Critical Role for the RNA Exosome in NeuronsSemantic proximity Read

RNA exosome-mediated RNA surveillance governs developmental timing in the human cerebellumSemantic proximity Read

The RNA exosome and RNA exosome-linked disease.Semantic proximity Read

Biallelic mutations in the 3' exonuclease TOE1 cause pontocerebellar hypoplasia and uncover a role in snRNA processing.Semantic proximity Read

The RNA Exosome and Human Disease.Semantic proximity Read

Analysis of RNA Exosome Subunit Transcript Abundance Across Tissues: Implications for Neurological Disease PathogenesisSemantic proximity Read

RNA exosome mutations in pontocerebellar hypoplasia alter ribosome biogenesis and p53 levels.Semantic proximity Read

Systematic comparison of pathogenic variants of the RNA exosome gene <i>EXOSC3/RRP40</i> in <i>Saccharomyces cerevisiae</i> reveals variant-specific functional consequencesSemantic proximity Read

EXOSC10-mediated pre-tRNA surveillance safeguards neuron survivalSemantic proximity Read

tRNA splicing endonuclease mutations cause pontocerebellar hypoplasia.Semantic proximity Read