Article
Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) Mutation and TRAP1 Inhibitor Gamitrinib-triphenylphosphonium (G-TPP) Induce a Forkhead Box O (FOXO)-dependent Cell Protective Signal from Mitochondria.
The Journal of biological chemistry - 22 Jan 2016
Kim Hyunjin, Yang Jinsung, Kim Min Ju, Choi Sekyu, Chung Ju-Ryung, Kim Jong-Min, Yoo Young Hyun, Chung Jongkyeong, Koh Hyongjong
Abstract excerpt
TRAP1 (tumor necrosis factor receptor-associated protein 1), a mitochondrial Hsp90 family chaperone, has been identified as a critical regulator of cell survival and bioenergetics in tumor cells. To discover novel signaling networks regulated by TRAP1, we generated Drosophila TRAP1 mutants. The mutants successfully developed into adults and produced fertile progeny, showing that TRAP1 is dispensable in...
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