Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impairment of oxidative stress-induced heme oxygenase-1 expression by the defect of Parkinson-related gene of PINK1.

Journal of neurochemistry - 1 May 2011

Chien Wei-Lin, Lee Tzeng-Ruei, Hung Shih-Ya, Kang Kai-Hsiang, Lee Ming-Jen, Fu Wen-Mei

Abstract excerpt

Parkinson's disease (PD) is one of the most common neurodegenerative diseases. Mutation in the phosphatase and tensin homolog (PTEN)-induced putative kinase 1 (PINK1) gene causes an autosomal recessive form of PD. However, the etiology related to PINK1 is still not clear. Here, we examined the effect of PINK1 on heme oxygenase (HO)-1 induction in SH-SY5Y neuronal cells following H(2)O(2) or...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Benzimidazoles
Share to Coloring Agents
Share to Heme Oxygenase-1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to HSP90 Heat-Shock Proteins

Share to L-Lactate Dehydrogenase

Share to Parkinson Disease, Secondary

Share to Tetrazolium Salts

Share to Thiazoles

Source

Identifiers

PMID: 21366594
DOI: 10.1111/j.1471-4159.2011.07229.x

Genes

PINK1
TRAP1
PTEN

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impairment of oxidative stress-induced heme oxygenase-1 expression by the defect of Parkinson-related gene of PINK1.PMID 21366594Read ↗

Antagonism of proteasome inhibitor-induced heme oxygenase-1 expression by PINK1 mutation.Semantic proximity Read ↗

Increase of oxidative stress by a novel PINK1 mutation, P209A.Semantic proximity Read ↗

Mutant PINK1 upregulates tyrosine hydroxylase and dopamine levels, leading to vulnerability of dopaminergic neurons.Semantic proximity Read ↗

NOX2-Derived Hydrogen Peroxide Impedes the AMPK/Akt-mTOR Signaling Pathway in Parkinson's Disease in Vitro ModelsSemantic proximity Read ↗

DJ-1 protects the nigrostriatal axis from the neurotoxin MPTP by modulation of the AKT pathwaySemantic proximity Read ↗

NRF2 Regulates PINK1 Expression under Oxidative Stress ConditionsSemantic proximity Read ↗

Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila.Semantic proximity Read ↗

PARK6 PINK1 mutants are defective in maintaining mitochondrial membrane potential and inhibiting ROS formation of substantia nigra dopaminergic neurons.Semantic proximity Read ↗

R492X mutation in PTEN-induced putative kinase 1 induced cellular mitochondrial dysfunction and oxidative stress.Semantic proximity Read ↗

TRAP1 rescues PINK1 loss-of-function phenotypesSemantic proximity Read ↗

Parkin protects human dopaminergic neuroblastoma cells against dopamine-induced apoptosis.Semantic proximity Read ↗

Loss of PINK1 function affects development and results in neurodegeneration in zebrafish.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.