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Article

Wnt2 overexpression protects against PINK1 mutant‑induced mitochondrial dysfunction and oxidative stress.

Molecular medicine reports - 1 Jun 2020

Xia Sui-Rui, Wen Xue-Yi, Fan Xiao-Li, Chen Xiao-Rong, Wei Zai-Wa, Li Qing-Hua, Sun Li

Abstract excerpt

The PTEN induced putative kinase 1 (PINK1) mutation is the second most common cause of autosomal recessive adolescent Parkinson's disease (PD). Furthermore, mitochondrial disorders and oxidative stress are important mechanisms in the pathogenesis of PD. Numerous members of the Wnt family have been found to be associated with neurodegenerative diseases. Therefore, the present study investigated the role of the...

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PMID: 32323790
DOI: 10.3892/mmr.2020.11066

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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