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Article

Arsenic trioxide extends survival of Li-Fraumeni syndrome mimicking mouse.

Cell death & disease - 29 Nov 2023

Li Jiabing, Xiao Shujun, Shi Fangfang, Song Huaxin, Wu Jiaqi, Zheng Derun, Chen Xueqin, Tan Kai, Lu Min

Abstract excerpt

Li-Fraumeni syndrome (LFS) is characterized by germline mutations occurring on one allele of genome guardian TP53. It is a severe cancer predisposition syndrome with a poor prognosis, partly due to the frequent development of subsequent primary tumors following DNA-damaging therapies. Here we explored, for the first time, the effectiveness of mutant p53 rescue compound in treating LFS-mimicking mice harboring a...

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Identifiers

PMID: 38030599
DOI: 10.1038/s41419-023-06281-2
PMCID: PMC10687230

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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