Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TRAP1 is involved in BRAF regulation and downstream attenuation of ERK phosphorylation and cell-cycle progression: a novel target for BRAF-mutated colorectal tumors.

Cancer research - 15 Nov 2014

Condelli Valentina, Piscazzi Annamaria, Sisinni Lorenza, Matassa Danilo Swann, Maddalena Francesca, Lettini Giacomo, Simeon Vittorio, Palladino Giuseppe, Amoroso Maria Rosaria, Trino Stefania, Esposito Franca, Landriscina Matteo

Abstract excerpt

Human BRAF-driven tumors are aggressive malignancies with poor clinical outcome and lack of sensitivity to therapies. TRAP1 is a HSP90 molecular chaperone deregulated in human tumors and responsible for specific features of cancer cells, i.e., protection from apoptosis, drug resistance, metabolic regulation, and protein quality control/ubiquitination. The hypothesis that TRAP1 plays a regulatory function on the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Cycle
Share to Cell Line, Tumor

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Colorectal Neoplasms

Share to Extracellular Signal-Regulated MAP Kinases

Share to HSP90 Heat-Shock Proteins

Share to Phosphorylation

Share to Proto-Oncogene Proteins B-raf

Share to Ubiquitination

Source

Identifiers

PMID: 25239454
DOI: 10.1158/0008-5472.CAN-14-1331

Genes

TRAP1
BRAF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TRAP1 is involved in BRAF regulation and downstream attenuation of ERK phosphorylation and cell-cycle progression: a novel target for BRAF-mutated colorectal tumors.PMID 25239454Read ↗

TRAP1 controls cell cycle G2–M transition through the regulation of CDK1 and MAD2 expression/ubiquitinationSemantic proximity Read ↗

Comprehensive pan-cancer analysis and experimental validation of TRAP1 as a possible medicinal targetSemantic proximity Read ↗

TRAP1 enhances Warburg metabolism through modulation of PFK1 expression/activity and favors resistance to EGFR inhibitors in human colorectal carcinomas.Semantic proximity Read ↗

TRAP1 regulates the response of colorectal cancer cells to hypoxia and inhibits ribosome biogenesis under conditions of oxygen deprivationSemantic proximity Read ↗

TRAP1, a novel mitochondrial chaperone responsible for multi-drug resistance and protection from apoptotis in human colorectal carcinoma cells.Semantic proximity Read ↗

Mitochondrial chaperone, TRAP1 as a potential pharmacological target to combat cancer metabolism.Semantic proximity Read ↗

Tumor Necrosis Factor Receptor-associated Protein 1 (TRAP1) Mutation and TRAP1 Inhibitor Gamitrinib-triphenylphosphonium (G-TPP) Induce a Forkhead Box O (FOXO)-dependent Cell Protective Signal from Mitochondria.Semantic proximity Read ↗

The Unfolded Protein Response: A Novel Therapeutic Target for Poor Prognostic BRAF Mutant Colorectal Cancer.Semantic proximity Read ↗

TRAP1 regulates stemness through Wnt/β-catenin pathway in human colorectal carcinoma.Semantic proximity Read ↗

TPT1 (tumor protein, translationally-controlled 1) negatively regulates autophagy through the BECN1 interactome and an MTORC1-mediated pathwaySemantic proximity Read ↗

Mutant-selective degradation by BRAF-targeting PROTACs.Semantic proximity Read ↗

Clinical and Cellular Roles for TDP1 and TOP1 in Modulating Colorectal Cancer Response to IrinotecanSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.