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Article

Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease.

Brain : a journal of neurology - 1 Sept 2017

Fitzgerald Julia C, Zimprich Alexander, Carvajal Berrio Daniel A, Schindler Kevin M, Maurer Brigitte, Schulte Claudia, Bus Christine, Hauser Anne-Kathrin, Kübler Manuela, Lewin Rahel, Bobbili Dheeraj Reddy, Schwarz Lisa M, Vartholomaiou Evangelia, Brockmann Kathrin, Wüst Richard, Madlung Johannes, Nordheim Alfred, Riess Olaf, Martins L Miguel, Glaab Enrico, May Patrick, Schenke-Layland Katja, Picard Didier, Sharma Manu, Gasser Thomas, Krüger Rejko

Abstract excerpt

The mitochondrial proteins TRAP1 and HTRA2 have previously been shown to be phosphorylated in the presence of the Parkinson's disease kinase PINK1 but the downstream signalling is unknown. HTRA2 and PINK1 loss of function causes parkinsonism in humans and animals. Here, we identified TRAP1 as an interactor of HTRA2 using an unbiased mass spectrometry approach. In our human cell models, TRAP1 overexpression is...

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Source

Identifiers

PMID: 29050400
DOI: 10.1093/brain/awx202

Genes

TRAP1
HTRA2
PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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