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Article

Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer.

Oncotarget - 29 Dec 2015

Zhang Bo, Wang Jing, Huang Zhen, Wei Peng, Liu Ying, Hao Junfeng, Zhao Lijing, Zhang Fenglin, Tu Yaping, Wei Taotao

Abstract excerpt

Tumor necrosis factor receptor-associated protein 1 (TRAP1) is abnormally expressed in many cancers. In this study, we showed that TRAP1 is aberrantly upregulated in breast tumors compared to control tissues. TRAP1 knockdown downregulates mitochondrial aerobic respiratory, sensitizes cells to lethal stimuli, and inhibited tumor growth in MDA-MB-231 and MCF-7 breast cancer cells in vivo. TRAP1 overexpression,...

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Source

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Identifiers

PMID: 26517089
DOI: 10.18632/oncotarget.6252
PMCID: PMC4792571

Genes

TRAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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