Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Loss of PINK1 function affects development and results in neurodegeneration in zebrafish.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Aug 2008

Anichtchik Oleg, Diekmann Heike, Fleming Angeleen, Roach Alan, Goldsmith Paul, Rubinsztein David C

Abstract excerpt

Parkinson's disease (PD) is the second most prevalent neurodegenerative disorder in the Western world. PTEN (phosphatase/tensin homolog on chromosome 10)-induced putative kinase 1 (PINK1), a putative kinase that is mutated in autosomal recessive forms of PD, is also implicated in sporadic cases of the disease. Although the mutations appear to result in a loss of function, the roles of this protein and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Axons
Share to Cell Death

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Nerve Degeneration

Share to Neurons

Share to Protein Kinases

Share to Zebrafish

Share to Zebrafish Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 18701682
DOI: 10.1523/JNEUROSCI.0979-08.2008
PMCID: PMC6670558

Genes

PINK1
PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Loss of PINK1 function affects development and results in neurodegeneration in zebrafish.PMID 18701682Read ↗

Loss of PINK1 in medaka fish (Oryzias latipes) causes late-onset decrease in spontaneous movement.Semantic proximity Read ↗

<i>TigarB</i> causes mitochondrial dysfunction and neuronal loss in PINK1 deficiencySemantic proximity Read ↗

PINK1 and Parkin complementarily protect dopaminergic neurons in vertebrates.Semantic proximity Read ↗

Inactivation of Pink1 Gene in Vivo Sensitizes Dopamine-producing Neurons to 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and Can Be Rescued by Autosomal Recessive Parkinson Disease Genes, Parkin or DJ-1Semantic proximity Read ↗

Loss-of-function rodent models for parkin and PINK1.Semantic proximity Read ↗

Impaired dopaminergic neuron development and locomotor function in zebrafish with loss of<i>pink1</i>functionSemantic proximity Read ↗

[Molecular genetics of PINK1].Semantic proximity Read ↗

A Critical Review of Zebrafish Models of Parkinson’s DiseaseSemantic proximity Read ↗

Dopaminergic cell damage and vulnerability to MPTP in Pink1 knockdown zebrafishSemantic proximity Read ↗

Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila.Semantic proximity Read ↗

Loss of PINK1 promotes the expansion of hematopoietic cells via upregulating autophagySemantic proximity Read ↗

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.