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Article

Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease.

Cell death & disease - 17 Jan 2013

Costa A C, Loh S H Y, Martins L Miguel

Abstract excerpt

Mitochondrial dysfunction caused by protein aggregation has been shown to have an important role in neurological diseases, such as Parkinson's disease (PD). Mitochondria have evolved at least two levels of defence mechanisms that ensure their integrity and the viability of their host cell. First, molecular quality control, through the upregulation of mitochondrial chaperones and proteases, guarantees the...

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Source

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Identifiers

PMID: 23328674
DOI: 10.1038/cddis.2012.205
PMCID: PMC3563993

Genes

PINK1
PTEN
TNF
TRAP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

Related research

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Research trail→

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Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease.PMID 23328674Read ↗

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PARIS induced defects in mitochondrial biogenesis drive dopamine neuron loss under conditions of parkin or PINK1 deficiencySemantic proximity Read ↗

PINK1-dependent phosphorylation of PINK1 and Parkin is essential for mitochondrial quality control.Semantic proximity Read ↗

Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in Parkinson's disease.Semantic proximity Read ↗

Genetic mutations and functions of PINK1.Semantic proximity Read ↗

PINK1 Is Selectively Stabilized on Impaired Mitochondria to Activate ParkinSemantic proximity Read ↗

DJ-1 acts in parallel to the PINK1/parkin pathway to control mitochondrial function and autophagy.Semantic proximity Read ↗

Atg1-mediated autophagy suppresses tissue degeneration inpink1/parkinmutants by promoting mitochondrial fission inDrosophilaSemantic proximity Read ↗

Mitochondrial dysfunction and Parkinson's disease genes: insights from Drosophila.Semantic proximity Read ↗

Hidden phenotypes of PINK1/Parkin knockout mice.Semantic proximity Read ↗

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