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Article

TRAP1 rescues PINK1 loss-of-function phenotypes

21 Mar 2013

Abstract excerpt

PTEN-induced kinase 1 (PINK1) is a serine/threonine kinase that is localized to mitochondria. It protects cells from oxidative stress by suppressing mitochondrial cytochrome c release, thereby preventing cell death. Mutations in Pink1 cause early-onset Parkinson's disease (PD). Consistently, mitochondrial function is impaired in Pink1-linked PD patients and model systems. Previously, in vitro analysis implied...

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PMID: 23525905
DOI: 10.1093/hmg/ddt132

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