Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity.

PLoS genetics - 1 Feb 2012

Butler Erin K, Voigt Aaron, Lutz A Kathrin, Toegel Jane P, Gerhardt Ellen, Karsten Peter, Falkenburger Björn, Reinartz Andrea, Winklhofer Konstanze F, Schulz Jörg B

Abstract excerpt

Overexpression or mutation of α-Synuclein is associated with protein aggregation and interferes with a number of cellular processes, including mitochondrial integrity and function. We used a whole-genome screen in the fruit fly Drosophila melanogaster to search for novel genetic modifiers of human [A53T]α-Synuclein-induced neurotoxicity. Decreased expression of the mitochondrial chaperone protein tumor necrosis...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Dopamine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dopaminergic Neurons

Share to HSP90 Heat-Shock Proteins

Share to Membrane Potential, Mitochondrial

Share to Molecular Chaperones

Share to PC12 Cells

Share to Rotenone

Source

Open in PubMed Open full text

Identifiers

PMID: 22319455
DOI: 10.1371/journal.pgen.1002488
PMCID: PMC3271059

Genes

TRAP1
PINK1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The mitochondrial chaperone protein TRAP1 mitigates α-Synuclein toxicity.PMID 22319455Read ↗

TRAP1 rescues PINK1 loss-of-function phenotypesSemantic proximity Read ↗

A53T Human α-Synuclein Overexpression in Transgenic Mice Induces Pervasive Mitochondria Macroautophagy Defects Preceding Dopamine Neuron DegenerationSemantic proximity Read ↗

Neuropathology in Mice Expressing Human α-SynucleinSemantic proximity Read ↗

Inhibition of copper transporter 1 prevents α-synuclein pathology and alleviates nigrostriatal degeneration in AAV-based mouse model of Parkinson's diseaseSemantic proximity Read ↗

Involvement of mortalin/GRP75/mthsp70 in the mitochondrial impairments induced by A53T mutant α-synuclein.Semantic proximity Read ↗

TP53INP1 exerts neuroprotection under ageing and Parkinson’s disease-related stress conditionSemantic proximity Read ↗

Conditional Expression of Parkinson's Disease-Related Mutant -Synuclein in the Midbrain Dopaminergic Neurons Causes Progressive Neurodegeneration and Degradation of Transcription Factor Nuclear Receptor Related 1Semantic proximity Read ↗

Drosophila Trap1 protects against mitochondrial dysfunction in a PINK1/parkin model of Parkinson's disease.Semantic proximity Read ↗

The Familial α-Synuclein A53E Mutation Enhances Cell Death in Response to Environmental Toxins Due to a Larger Population of Oligomers.Semantic proximity Read ↗

Inhibition of α-synuclein aggregation by MT101-5 is neuroprotective in mouse models of Parkinson’s diseaseSemantic proximity Read ↗

α-Synuclein Transgenic Mice Reveal Compensatory Increases in Parkinson's Disease-Associated Proteins DJ-1 and Parkin and Have Enhanced α-Synuclein and PINK1 Levels After Rotenone TreatmentSemantic proximity Read ↗

Synphilin-1 attenuates neuronal degeneration in the A53T -synuclein transgenic mouse modelSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.