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Article

Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.

Proceedings of the National Academy of Sciences of the United States of America - 5 Feb 2008

Haque M Emdadul, Thomas Kelly J, D'Souza Cheryl, Callaghan Steve, Kitada Tohru, Slack Ruth S, Fraser Paul, Cookson Mark R, Tandon Anurag, Park David S

Abstract excerpt

PTEN-induced putative kinase 1 (Pink1) is a recently identified gene linked to a recessive form of familial Parkinson's disease (PD). The kinase contains a mitochondrial localization sequence and is reported to reside, at least in part, in mitochondria. However, neither the manner by which the loss of Pink1 contributes to dopamine neuron loss nor its impact on mitochondrial function and relevance to death is...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 18218782
DOI: 10.1073/pnas.0705363105
PMCID: PMC2234210

Genes

PTEN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Cytoplasmic Pink1 activity protects neurons from dopaminergic neurotoxin MPTP.PMID 18218782Read ↗

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