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Article

Overexpression of myeloid differentiation protein 88 in mice induces mild cardiac dysfunction, but no deficit in heart morphology.

Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas - 1 Jan 2016

Chen W, Huang Z, Jiang X, Li C, Gao X

Abstract excerpt

Cardiac remodeling involves changes in heart shape, size, structure, and function after injury to the myocardium. The proinflammatory adaptor protein myeloid differentiation protein 88 (MyD88) contributes to cardiac remodeling. To investigate whether excessive MyD88 levels initiate spontaneous cardiac remodeling at the whole-organism level, we generated a transgenic MyD88 mouse model with a cardiac-specific...

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Identifiers

PMID: 26628395
DOI: 10.1590/1414-431X20154794
PMCID: PMC4681416

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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