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Article

MyD88 as a therapeutic target for inflammatory lung diseases

16 Apr 2018

Abstract excerpt

INTRODUCTION: Myeloid differentiation primary response protein 88 (MyD88) is a critical adaptor protein involved in Toll-like and IL-1 receptor family signaling controlling innate immune responses and inflammation. Genetic deletion of MyD88 function results in profound suppression of inflammation and reduced resistance of the host to pathogens indicating non-redundant roles of MyD88. The TIR domain is critical...

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PMID: 29658361
DOI: 10.1080/14728222.2018.1464139

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